Single-Dose DMT Triggers Rapid Depression Relief in Early Trial

In a double-blind, placebo-controlled trial with 34 adults suffering from treatment-resistant major depressive disorder, a single intravenous dose of DMT with psychotherapeutic support produced a rapid and meaningful reduction in depressive symptoms within a week, with effects lasting up to three months (some in remission for six months); the dose appeared safe with mostly mild side effects, though blinding was challenged by noticeable psychedelic effects and the small sample size calls for larger trials.