Different Brain Pathways Underlie Psilocybin and Escitalopram's Antidepressant Effects

A study comparing psilocybin and escitalopram for depression found that while both improve mood, they affect brain responses to emotional stimuli differently; escitalopram reduces brain activity linked to emotions, potentially causing emotional blunting, whereas psilocybin preserves or enhances emotional responsiveness, suggesting different mechanisms of action.