Genetic Insights into Human Metabolism and Blood Molecule Levels
TL;DR Summary
A large-scale study using whole-genome sequencing in over 700,000 individuals identified new genetic factors influencing metabolic health, including genes like IRS2 linked to type 2 diabetes and kidney disease, highlighting the benefits of WGS over exome sequencing for understanding complex traits.
Topics:health#bmi#genome-wide-association#health-and-genetics#metabolic-health#t2d#whole-genome-sequencing
- Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health Nature
- A genetic map of human metabolism across the allele frequency spectrum Nature
- Study links 750 genes' role in metabolism via impact on blood levels of molecules The Hindu
- How genes affect our metabolism Berlin Institute of Health
- Study identifies hundreds of genes, including novel ones, governing blood molecule levels News-Medical
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