E. coli Strain Evades Gut Defenses to Promote Infection
TL;DR Summary
The bacterial effector NleL inhibits pyroptosis and cell extrusion in intestinal epithelial cells by targeting caspase-4 and ROCK2 for proteasomal degradation through ubiquitylation, thereby promoting bacterial colonization and infection in the gut.
- Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion Nature
- Dangerous E. coli strain blocks gut's defense mechanism against spreading infection Medical Xpress
- Pathogenic Bacteria Outsmart Epithelial Cell Defense Bioengineer.org
- How Dangerous E. coli Strain Eludes Gut’s Defense Mechanism: New Study TUN - The University Network
- New Study Reveals How Dangerous E. coli Strain Disables Gut Defenses to Propel Infection Bioengineer.org
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