Christina Applegate Details Early MS Clues That Preceded Her Diagnosis

Christina Applegate reveals in her memoir and interviews that subtle warning signs of multiple sclerosis, including toe twitching and balance issues, appeared years before her 2021 diagnosis. A 2021 Zoom brain MRI reportedly showed around 30 lesions; she describes escalating pain, numbness, and mobility challenges that worsened over time, and discusses MS as her constant companion while highlighting her ongoing efforts to cope, including a podcast about the condition with Jamie-Lynn Sigler.