MOSAIC harnesses collective AI to accelerate chemical synthesis and new reactions

Nature previews MOSAIC, a framework that pools millions of reaction protocols into 2,498 specialized chemical experts anchored in Voronoi-clustered spaces on Llama-3.1-8B-instruct, delivering reproducible, executable synthesis protocols with confidence metrics. In experimental tests, MOSAIC achieved a 71% success rate and enabled the synthesis of over 35 novel compounds across pharmaceuticals, materials, agrochemicals, and cosmetics, including new reaction methodologies not present in the training data.