The Role of Therapy-induced APOBEC3A in Cancer Cell Evolution

Therapy-induced APOBEC3A, a protein involved in DNA mutation, drives the evolution of persistent cancer cells and contributes to treatment resistance. Whole-genome and -exome sequencing data on clinical tumor samples and experimental models are available for further analysis. The study highlights the importance of understanding the role of APOBEC3A in cancer evolution and suggests potential therapeutic strategies to target this protein.