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Tumor Suppressors

All articles tagged with #tumor suppressors

health1 year ago•3 min saved

Mutant Proteins' Unexpected Role in Cancer Progression Unveiled

Researchers at the NIH have discovered a new role for mutant RAS proteins in cancer progression, revealing that they help release the EZH2 protein from a nuclear complex, leading to the breakdown of the tumor suppressor protein DLC1. This finding suggests that combining RAS inhibitors with drugs that reactivate DLC1 could enhance cancer treatment efficacy, particularly in RAS-driven cancers like pancreatic, colorectal, and lung cancers. The study highlights potential new treatment strategies for these aggressive cancers.

via National Institutes of Health|

#cancer #ezh2 #health

health2 years ago•0 min saved

Smoking's DNA Mutations Fuel Cancer Growth, Study Finds

A new study confirms that smoking tobacco can cause DNA mutations, known as "stop-gain mutations," that lead to cancer. These mutations instruct the body to stop producing specific proteins, hindering their ability to protect against cancer. The study also found that tumor-suppressor genes, which produce proteins that block abnormal cell growth, were particularly affected by these mutations, resulting in uncontrolled cancer cell proliferation.

via Interesting Engineering|

#cancer #dna-mutations #health

health2 years ago•2 min saved

Smoking hinders cancer defenses, making treatment more difficult: Study

A study conducted by scientists at the Ontario Institute for Cancer Research has revealed that tobacco smoking causes cancer and makes it more difficult to treat by interfering with the body's cancer-fighting proteins. The study found that smoking leads to harmful changes in DNA known as 'stop-gain mutations,' which disrupt the formation of tumor suppressor proteins that prevent abnormal cell growth. The researchers also discovered that the amount of smoking directly correlates with the number of these mutations, making cancer more complex and resistant to treatment. The study highlights the damaging effects of smoking on DNA and emphasizes the importance of quitting smoking to reduce the risk of cancer.

via Medical Xpress|

#cancer #dna-mutations #health