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Slime Mold Enzyme

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Tagatose: The insulin-friendly, heat-stable sugar poised for mass production
science1 day ago

Tagatose: The insulin-friendly, heat-stable sugar poised for mass production

Tufts researchers, using a slime-mold Gal1Pase enzyme, engineered E. coli to convert glucose to tagatose with a 95% yield, enabling scalable, lower-cost production. Tagatose is nearly as sweet as sugar but with about one-third the calories and does not trigger insulin spikes, making it attractive for diabetes management. It’s heat-stable for baking, is considered safe by FDA/WHO, and could reach a $250 million market by 2032, though individuals with fructose intolerance should avoid it.

Bioengineered Pathway Boosts Production of Sweet, Low-Calorie Tagatose
science3 days ago

Bioengineered Pathway Boosts Production of Sweet, Low-Calorie Tagatose

Researchers engineered E. coli to produce tagatose by introducing a slime mold Gal1P enzyme, achieving up to 95% yield; tagatose is a rare, naturally occurring sugar about 92% as sweet as sucrose with roughly a third of the calories and no insulin spike, offering a scalable alternative to sugar and artificial sweeteners; the study lays a framework for rare-sugar production, with the market expected to reach around $250 million by 2032.