"Revolutionary Lung Gene Editing Techniques Utilizing Novel Nanoparticles and Lipids"
Researchers have developed a new method for delivering CRISPR RNA to the lungs using improved lipid nanoparticles. By synthesizing and screening 720 novel lipids, the authors identified a nanoparticle formulation that achieves moderately efficient editing in the mouse lung after intratracheal delivery of CRISPR RNA-LNPs. This achievement paves the way for therapeutic CRISPR applications in the lung that involve not only gene editing but also gene therapy. The approach should aid the discovery of gene-editing drugs that are effective in treating lung diseases in animal models and, with further optimization, could provide an enabling technology for clinical applications.