Mountain Gene Triggers Innate Nerve Repair Pathway for Myelin Recovery
A gain-of-function mutation in the high-altitude Retsat gene helps restore myelin and promote nerve repair in mice by boosting vitamin A–derived metabolites that support oligodendrocyte maturation. The study, published in Neuron (March 13, 2026), suggests a natural, body-made pathway to treat myelin-related conditions such as multiple sclerosis and cerebral palsy, potentially reducing the need for immune-targeting drugs by enhancing innate regenerative processes.