Female mice are more resistant to obesity and inflammation compared to males due to a higher secretion of the immune protein RELMalpha, according to a study conducted at the University of California, Riverside. The study identified a crucial 'RELMalpha-eosinophil-macrophage axis' in females, offering potential novel therapies to combat obesity. The findings emphasize the importance of considering sex differences in tackling metabolic diseases and highlight RELMalpha as a promising therapeutic target.
Female mice are found to be protected against obesity and inflammation compared to males due to their secretion of an immune protein called RELMalpha, according to a study conducted by scientists at the University of California, Riverside. The study reveals that RELMalpha regulates immune cell types, such as anti-inflammatory macrophages and eosinophils, which play a crucial role in protecting against obesity. Deleting RELMalpha in female mice resulted in obesity and reduced levels of eosinophils, similar to male mice. However, treating female mice with eosinophils or RELMalpha reduced obesity, suggesting potential therapeutic targets. The study emphasizes the importance of considering sex differences in tackling metabolic diseases like obesity.
