Factors influencing treatment adherence and disability progression in MS patients: A UK study
A new study challenges the traditional belief that relapses are the main driver of disability worsening in early relapsing forms of multiple sclerosis (MS). The study found that most disability worsening events occur independent of relapse activity across all types of MS, including clinically isolated syndrome (CIS) and early relapsing-remitting MS (RRMS). This suggests that progression without relapses, known as progression independent of relapse activity (PIRA), is not exclusive to progressive forms of the disease. The findings highlight the need for a standardized definition of PIRA and further research to better understand and measure disability in MS.
