"RalA Activation: Unraveling Obesity's Impact on Mitochondrial Function"
Originally Published 1 year ago — by Nature.com
Obesity leads to mitochondrial dysfunction in white adipocytes due to increased RalA activity, contributing to metabolic abnormalities. Deletion of RalA in white adipocytes attenuates high-fat-diet-induced obesity, increases energy expenditure, and improves glucose homeostasis in mice. RalA deletion also reduces hepatic steatosis and damage, while increasing mitochondrial oxidative phosphorylation in white adipose tissue.