"Potential Link Between Daily Proton-Pump Inhibitor Use and Dementia/Neuropathy"
A retired individual with Barrett's esophagus and concerns about the effects of proton-pump inhibitors (PPIs) on dementia and neuropathy seeks advice from Dr. Keith Roach. While studies on the link between PPIs and atrial fibrillation (AFib) are inconclusive, the risk of esophageal cancer due to untreated acid reflux in Barrett's esophagus patients is a key concern. Dr. Roach recommends PPIs over H2 blockers for reducing the risk of esophageal cancer, despite known risks such as potential B12 deficiency and neuropathy. He emphasizes the importance of routine endoscopic surveillance and biopsies for early detection and treatment of any abnormal esophageal growth.