Revolutionary Spectroscopy Technique Shatters 50 Years of Frustration
Researchers from Texas A&M University and TEES have developed a new technique called thermostable-Raman-interaction-profiling (TRIP) that overcomes the limitations of Raman spectroscopy in damaging live proteins during optical measurements. TRIP allows low-concentration, low-dose screenings for protein-to-ligand interactions in physiologically relevant conditions, enabling label-free, highly reproducible measurements. This breakthrough has potential applications in rapid and cost-effective drug, vaccine, and virus testing, as well as DNA analysis. The TRIP technique offers real-time detection of protein-ligand interactions, shortening the timeline for testing and providing accurate results. Additionally, the TRIP method requires smaller sample sizes and lower protein concentrations, making it a more cost-effective process.
