"Breakthrough: Unveiling Promising Drug Targets for Rare Brain Disorder PSP"
Researchers have identified potential therapeutic targets for progressive supranuclear palsy (PSP), an incurable brain disorder with symptoms similar to Parkinson's and dementia. By analyzing RNA sequencing data from over 400 brain samples, the study identified nearly 5,000 genes associated with PSP. Among the high-confidence genes, reducing levels of DDR2, KANK2, and STOM showed promise in reversing the disease. This research enhances understanding of PSP and other related neurological disorders, providing potential targets for future treatments. The next steps involve synthesizing small nucleic acid molecules to regulate the target genes and assessing their safety and efficacy in cell and animal models.