Ice-Age Mother-Daughter Skeletons Reveal Earliest AMDM Case
Ancient DNA analysis of two closely related Ice Age skeletons from Romito Cave in Italy identifies a mother–daughter pair, with the younger diagnosed with acromesomelic dysplasia, Maroteaux type (AMDM) caused by NPR2 mutations—the earliest known AMDM case. The study highlights how a family carried a gene variant affecting bone growth and shows care within the group; findings were published in The New England Journal of Medicine.