Unveiling the Comprehensive Atlas of Human Kidney Cells for Advancing Disease Research
Researchers have created a comprehensive cellular atlas of healthy and diseased human kidneys, providing a high-resolution view of 51 main cell types and 28 cellular states across nephron segments and interstitium. The atlas, generated through multiple single-cell and single-nucleus assays, as well as spatial imaging technologies, offers detailed transcriptomic profiles, regulatory factors, and spatial localizations. It also identifies molecular signatures associated with injury and repair processes, providing insights into the progression of acute kidney injury to chronic kidney disease. The atlas serves as a valuable resource for understanding kidney pathophysiology and developing targeted therapies.