Silent Onset of Rheumatoid Arthritis Detected Years Before Symptoms
Scientists have discovered that rheumatoid arthritis (RA) begins years before symptoms appear, with changes in immune system profiles detectable in at-risk individuals. Elevated autoantibodies like ACPA and RF can predict RA development, but not all with these antibodies develop the disease. Recent research highlights immune system alterations, such as increased inflammatory proteins and activated B and T cells, in individuals before clinical symptoms emerge, offering potential for early detection and preventive therapies. These findings could lead to interventions that prevent or mitigate RA progression.