Black Ginseng Shows Molecular Promise in Slowing Inflammatory Skin Aging
New research indicates black ginseng extract (BGE), rich in rare ginsenosides formed during processing, may counter inflammation-driven skin aging by reducing MMP-1 expression and prostaglandin E2 while increasing TIMP-1 in human fibroblasts and a 3D skin model; docking studies suggest ginsenosides Rg3, Rg5, and RK1 bind to inflammation- and aging-related proteins, highlighting BGE’s potential as a cosmetic/dermatology ingredient to preserve collagen and skin structure. Further work is needed to fully map the pathways involved.