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E3 Ligase

All articles tagged with #e3 ligase

science-and-research1 year ago

"UFM1 E3 Ligase: Releasing 60S Ribosomes from ER Translocons"

The UFM1 E3 ligase complex, UREL, recognizes and releases 60S ribosomes from the endoplasmic reticulum (ER) translocons. It preferentially UFMylates free 60S ribosomal subunits, with the main target being the 60S ribosomal-subunit protein RPL26. The cryo-electron microscopy (cryo-EM) structure of the UREL complex bound to 60S ribosomes reveals its clamp-like architecture and its interaction with ribosomal proteins. The UREL complex uses a scaffold-type mechanism to bind to charged UFC1~UFM1 before transferring UFM1 onto a substrate lysine. The study sheds light on the mechanism of this unusual E3 ligase and its role in the release of stalled and terminated ribosomes from the SEC61 translocon.

via Nature.com|
#e3-ligase#ribosomes#science-and-research
science-and-research1 year ago

"E3 Ligase Mutation Silences Stress Response in Neurodegeneration"

Researchers have discovered that stress response silencing is a regulated process linked to human disease, particularly neurodegeneration. They found that an E3 ligase called SIFI plays a crucial role in terminating the response to mitochondrial protein import stress by inducing the degradation of unimported mitochondrial precursors and stress response components. SIFI's dysfunction is associated with ataxia and early-onset dementia, and restoring stress response silencing could potentially offer new treatment approaches for neurodegenerative diseases caused by mitochondrial import defects.

via Nature.com|
#e3-ligase#mitochondrial-import#neurodegeneration