Unveiling the Hidden Connection: Cancer's Dual Hallmarks Revealed
Scientists have discovered a previously unknown link between chromosomal instability and epigenetic changes, both of which are hallmarks of cancer. This connection allows individual cancer cells within the same tumor to develop variations, increasing their survival and resistance to treatment. The findings open up new possibilities for treatment and provide insights for further research. Chromosomal instability and the presence of micronuclei could be used as biomarkers to identify patients who may benefit from epigenetic modifying drugs. The study also suggests that targeting chromosomal instability and suppressing epigenetic alterations simultaneously could be a promising therapeutic approach. Additionally, preventing the rupture of micronuclei, a driver of epigenetic changes, could be explored as a potential strategy.