Unveiling the Genetic Roots of Autism Spectrum Disorder: Artificial Brain's Breakthrough
Scientists have developed a new technique called CHOOSE, which uses brain organoids to study the genetic origins of autism spectrum disorder (ASD). By analyzing mutations of high-risk autism genes in individual cells within the organoids, researchers can understand how these mutations lead to specific changes in the fetal brain. The study focused on 36 known high-risk autism genes and found that different cell types in the brain can be vulnerable to autism-related mutations. This technique has the potential to significantly advance our understanding of genetic diseases and could be applied to study disease-associated genes beyond brain organoids.