
Identified cause of severe liver damage in children outbreak.
Childhood viruses, including adeno-associated virus 2 (AAV2), may have caused the mysterious outbreak of severe liver damage in children that began in late 2021. Researchers found that AAV2 needed "helper" viruses to get into liver cells, and in 93% of the cases investigated, they detected AAV2. The study focused on 16 U.S. children with severe hepatitis, analyzing samples of blood, stool, and liver biopsies. In a majority of the cases, patients were infected with three or four common viruses at the same time. The findings do not prove that co-infections directly caused the severe hepatitis, but give important clues.
