"Unveiling the Immune Response: Single-Cell Resolution Cytokine Dictionary"
Researchers have created a comprehensive dictionary of immune responses to cytokines at single-cell resolution. Using single-cell transcriptomic analysis, they profiled the responses of more than 17 immune cell types to 86 different cytokines in mouse lymph nodes. The study revealed cell-type-specific gene expression changes and identified distinct polarization states induced by cytokines in each cell type. The findings provide a molecular map of immune responses to cytokines and shed light on the complex interactions between cytokines and immune cells.