Low-Side Effect Antidepressant Eases Stress and Depression.
Scientists have developed a new anti-depressant drug, KNT-127, that exhibits anti-stressing and anti-depressant effects with minimal side effects. The drug is a potent delta opioid receptor (DOP) agonist with significant anti-depressant activity and quick action. In a mouse model of depression, prolonged administration of KNT-127 during and after stress significantly improved social interaction, reduced neuronal inflammation, and suppressed stress-induced newborn neuronal death in the hippocampus. The anti-stress effect of KNT-127 may offer added benefits for patients during treatment.