Real-World Effectiveness of Weight-Loss Drugs Falls Short of Clinical Trial Results
TL;DR Summary
A Cleveland Clinic study found that in real-world settings, injectable obesity medications semaglutide and tirzepatide lead to smaller weight loss compared to clinical trials, mainly due to treatment discontinuation and lower dosages, with discontinuation also negatively impacting blood sugar control in prediabetic patients.
- Cleveland Clinic Research Finds Injectable Medications for Obesity Produce Smaller Weight Loss in A Real-World Setting, Compared to Randomized Clinical Trials Cleveland Clinic Newsroom
- Real-World Use of GLP-1s Yields Less Weight Loss Than Clinical Trials AJMC
- Real-World Results For GLP-1 Drugs Underwhelm, Study Says U.S. News & World Report
- Weight loss drugs don’t work as well for people in the real world, physicians find The Independent
- New ‘weight-loss’ drugs have lower impact in real life compared to clinical trial results: study The Hindu
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