Personality plays a role in oxytocin's impact on psychiatric symptoms.

The effects of oxytocin on psychiatric symptoms depend on personality characteristics, according to a study of hospitalized patients with severe mental illness in Israel. Oxytocin administration improved symptoms in participants low in openness and extraversion, but led to a deterioration of the working alliance with the therapist in participants low in agreeableness and neuroticism. The study sheds light on the effect of oxytocin on important psychological processes, but also has limitations that need to be taken into account.