Oprah Winfrey Reframes Weight Loss with Science and Self-Compassion

Oprah Winfrey reflects on decades of weight struggles, describing a biologically driven “enough point” and a shift from self-blame to a science-informed approach outlined in her book Enough with Dr. Ania Jastreboff. After resisting weight-loss medications for years due to shame, she started GLP-1–type drugs about two years ago, paired with daily hiking and resistance training, and now weighs about 155 pounds—the marathon weight—and says she feels healthier and stronger at 71 than at 40. Medical experts emphasize obesity as a treatable disease, not a personal fault, and Oprah’s openness aims to reduce stigma and encourage sustainable, health-focused strategies.