Neuroimaging News

Polygenic anhedonia risk linked to altered reward-brain activity

A German neuroimaging study found that individuals with higher polygenic risk scores for anhedonia show distinct brain activity during a monetary incentive delay task: they exhibit decreased activation in the bilateral putamen and left middle frontal gyrus during reward anticipation and reduced right caudate activity during reward feedback. Higher risk is also associated with lower activity in the left middle frontal gyrus when anticipating losses and during salience processing, while there is heightened activity in the bilateral putamen and right caudate during loss feedback. The results highlight the involvement of striatal and prefrontal circuits in genetic risk for anhedonia, though replication and further research are needed.