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Viral Reservoir

All articles tagged with #viral reservoir

Advancements in HIV Cure Research: Gut Health and Kidney Transplants Show Promise

Originally Published 2 years ago — by Emory News Center

Researchers at Emory University have presented exciting findings in the pursuit of an HIV cure. The study demonstrated the potential of Jak inhibitors, specifically ruxolitinib, to significantly decay the viral reservoir in people with HIV, offering a novel pathway toward long-term remission or a cure. The results showed an estimated 99.99% clearance of the peripheral HIV-1 reservoir in less than three years. The study also highlighted the impact of ruxolitinib on immune activation, cell survival, and immune dysregulation. While further research and clinical trials are needed, these findings offer hope for the development of cure-based interventions for HIV.

health health emory-university health hiv-cure-research jak-inhibitors long-term-remission viral-reservoir

Long-term HIV persistence in myeloid cells despite antiretroviral therapy

Originally Published 2 years ago — by National Institutes of Health (.gov)

A new study supported by the National Institutes of Health has found that a subset of white blood cells known as myeloid cells can harbor HIV in people who have been virally suppressed for years on antiretroviral therapy. The study suggests that myeloid cells contribute to a long-lived HIV reservoir, making these cells an important but overlooked target in efforts to eradicate HIV. The researchers note that larger studies with more diverse participant pools will be essential to accurately estimate the proportion of people who have latent HIV in myeloid cells.

health health antiretroviral-therapy cure-efforts health hiv myeloid-cells viral-reservoir