"Shapeshifting DNA-Repair Protein Complex Unveiled: Insights from Georgia State Researchers"
Researchers have discovered that the protein complex TFIIH, which plays critical roles in transcription and DNA repair, is a shapeshifter that reconfigures itself to meet the demands of each task. By conducting molecular dynamics simulations, the team found that TFIIH undergoes structural changes to carry out its functions. Understanding the inner workings of TFIIH is crucial for understanding genetic disorders caused by mutations and could lead to the development of therapeutic strategies. The research provides insights into the mechanical dynamics of TFIIH and its role in DNA repair and transcription initiation.