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Preclinical Data

All articles tagged with #preclinical data

health-and-medicine1 year ago•5 min saved

"Palisade Bio's PALI-2108 Shows Promise, Stock Surges 150%"

Palisade Bio presented positive preclinical data of its lead program PALI-2108 at the 2024 Crohn’s & Colitis Congress, demonstrating its safety, local activity, and low systemic exposure for the treatment of moderate-to-severe ulcerative colitis. The orally delivered and colon-activated PALI-2108 is advancing toward a Phase 1 clinical study expected to commence in 2024, with promising outcomes including colon-specific distribution, dose-dependent efficacy in a mouse UC model, and no systemic toxicity in dogs, offering potential for revolutionizing UC treatment.

via GlobeNewswire|

#crohns-and-colitis-congress #health-and-medicine #pali-2108

healthcare2 years ago•5 min saved

CRISPR Therapeutics Unveils Groundbreaking Preclinical Data at AHA Scientific Sessions 2023

CRISPR Therapeutics announced preclinical data at the American Heart Association (AHA) Scientific Sessions 2023, showcasing the potential of their investigational gene editing therapies, CTX310 and CTX320, for the treatment of cardiovascular disease. CTX310 demonstrated durable reductions in angiopoietin-like 3 protein (ANGPTL3) and triglyceride levels in non-human primates (NHPs) after a single dose, while CTX320 led to durable reductions in lipoprotein(a) (Lp(a)) levels in NHPs. Both therapies were well-tolerated. CTX310 has initiated a clinical trial targeting ANGPTL3, while CTX320 is on track to enter the clinic in the first half of 2024. The data suggest that these therapies have the potential to shift the treatment paradigm for cardiovascular disease towards a potentially one-time, durable therapy.

via Yahoo Finance|

#cardiovascular-disease #crispr-therapeutics #ctx310