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Flat Affect

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Weight‑loss drugs that dull the spark: GLP-1 apathy explored
explain-it-to-me5 hours ago

Weight‑loss drugs that dull the spark: GLP-1 apathy explored

GLP-1 weight‑loss medications are surging in use, with users commonly reporting fatigue and nausea, but clinicians are noting a striking side effect: extreme apathy or a “flat” emotional state that isn’t classic depression. Experts say it may involve dopamine and motivation pathways, making the net impact nuanced and highly dependent on individual circumstances as more people start these therapies.