"Combination Therapy Shows Promise in Advanced Biliary Tract Cancer Treatment"
TL;DR Summary
Pembrolizumab, an immune checkpoint inhibitor, in combination with gemcitabine and cisplatin, has been found to improve overall survival in patients with advanced biliary tract cancer compared to gemcitabine and cisplatin alone, according to a phase 3 trial. The study involved 1,069 patients and found that the pembrolizumab group had a median overall survival of 12.7 months compared to 10.9 months in the placebo group. The combination therapy could be a new treatment option for patients with previously untreated metastatic or unresectable biliary tract cancer.
- Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial The Lancet
- Merck clashes with AstraZeneca in biliary tract cancer FiercePharma
- AACR 2023 – more hope for Moderna’s neoantigen immunotherapy Evaluate Pharma
- Pembrolizumab Plus Gemcitabine/Cisplatin Provided Significant Improvement in OS in Advanced Biliary Tract Cancer Pharmacy Times
- Moderna and Merck Announce mRNA-4157 (V940), an Investigational Individualized Neoantigen Therapy, in Combination with KEYTRUDA(R) (Pembrolizumab), Demonstrated Superior Recurrence-Free Survival in Patients with High-Risk Stage III/IV Melano Yahoo Finance
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