Unveiling RNA Modification: Targets for Therapeutic Advancements
A comprehensive review discusses the mechanisms and therapeutic targets of RNA modifications, including m6A, m5C, m1A, m7G, Ψ, and A-to-I editing. The review explores the role of RNA modifying enzymes as "writers," "erasers," and "readers" in regulating mRNA stability, translation, and localization. It also highlights the dysregulation of specific RNA modifiers in various diseases and lists promising small molecule inhibitors targeting RNA modifiers. The review provides insights for future research and the development of RNA-modification-targeted therapeutic strategies.