Resident Evil Requiem’s Endgame Puzzle Stumps Players and Reviewers

TL;DR Summary
Kotaku reports that Resident Evil Requiem features a sprawling “Final Puzzle” that has stumped players even after launch. The puzzle starts late in Act 1 when Grace escapes The Girl; picking up the severed hand and scanning it at a microscope yields an RNA-like sequence, “GGC AAG AUA ACG UGU CAU,” which hints at codes for safes and unlocks further clues that increasingly rely on knowledge outside the game. Guides from IGN are being updated as players and outlets chase the solution, and the in-game goal hints that the finale will be reached when “the sweet pair hear the voice.” A solution seems imminent, but no definitive answer has surfaced yet.
- There’s A Game-Long Resident Evil Requiem Puzzle No One’s Been Able To Solve Kotaku
- All Puzzle Box Solutions In Resident Evil Requiem GameSpot
- Final Challenge Puzzle Solution IGN
- Resident Evil 9 Requiem: How to use the Severed Hand Video Games Chronicle
- Resident Evil Requiem Walkthrough: Rhodes Hill 2 (The Quartz pieces & Victor's Office) Rock Paper Shotgun
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